>> Dr. Terry Simpson: Chances are you know someone who has been on

Ozempic.

>> Dr. Terry Simpson: Maybe you've heard someone whisper at brunch.

>> Dr. Terry Simpson: That they're on the shot.

>> Dr. Terry Simpson: Or maybe you've seen some of the headlines about some of the miracles that.

>> Dr. Terry Simpson: The GLP1s like Ozempic and Zeppbound can

do.

>> Dr. Terry Simpson: Today we're going to talk about those.

>> Dr. Terry Simpson: GLP1 Ozempic, also known as

WeGovy, Zeppbound.

>> Dr. Terry Simpson: Also known as Terzepzide or Manjaro. These are

not diet pills. These are precision

metabolic therapies.

>> Dr. Terry Simpson: And no, the real magic is not in your

gut. The real magic is in your

brain.

>> Dr. Terry Simpson: I'm your Chief Medical Explanationist, Dr. Terri.

>> Dr. Terry Simpson: Simpson, and this is Fork U Fork

University, where we make sense of the madness,

bust a few myths, and teach you a little bit about food

and medicine.

>> Dr. Terry Simpson: Here's how the GLP1s work.

>> Dr. Terry Simpson: Work in your brain.

>> Dr. Terry Simpson: Now, if you remember neuroanatomy, you are.

>> Dr. Terry Simpson: Going to love the next three sentences.

If not, just hang in there. You'll learn some

fancy words and it's okay to use them.

GLP ones work in something called the

hypothalamus, where they activate satiety

neurons and suppress hunger. Got that so

far. Right. In the mesolimbic

reward system, the ventral.

>> Dr. Terry Simpson: Tigeminal area and the nucleus accumbens, they.

>> Dr. Terry Simpson: Reduce dopamine release, blunting food's

reward effect. They also modulate

serotonin, impacting mood, reducing.

>> Dr. Terry Simpson: Emotional eating, and improving satiety.

>> Dr. Terry Simpson: Okay, you got through it.

>> Dr. Terry Simpson: Here's the bottom.

>> Dr. Terry Simpson: Food noise is gone.

When you hear people saying that, they're not just

manifesting, they are describing, uh, a

complex neurochemistry that

we have never heard before,

people talking about food noise being gone.

>> Dr. Terry Simpson: We've also seen it in patients who've taken these drugs, and

they've noticed that.

>> Dr. Terry Simpson: They have a decreased interest in alcohol

or tobacco. There are more things that

GLP1s do, and we're going to talk about some of those a little

bit.

>> Dr. Terry Simpson: But these drugs literally

rewire the drive to eat.

It's not just a sensation of fullness.

What makes them transformative is in the brain.

It's not the nausea, it's not the gastric slowing.

>> Dr. Terry Simpson: Those help, but that's not the primary

mechanism.

>> Dr. Terry Simpson: And now I want to address the.

>> Dr. Terry Simpson: Influencer lie or quack lie of the Week.

>> Dr. Terry Simpson: You've seen them. Natural GLP1 Boosters

or Buy youy Natural GLP1. The

reason these quacks have that form is because the

pharmaceutical companies are still.

>> Dr. Terry Simpson: Charging too much for the GLP1s.

>> Dr. Terry Simpson: But yes, let's start with the obvious. Your body

produces GLP1. It produces it in the

distal part of the small bowel. And fiber

rich foods which change your microbiome

enhance the production of your own natural

GLP1. And we also

discovered that some ultra processed junk

foods not only blunt production of

GLP1, but they actually

destroy the cells.

>> Dr. Terry Simpson: Well, the food doesn't.

>> Dr. Terry Simpson: The food causes you to have an increase in a certain

bacteria which actually.

>> Dr. Terry Simpson: Destroy cells that make your own

GLP1. What about your

GLP1?

>> Dr. Terry Simpson: It is metabolized in minutes.

>> Dr. Terry Simpson: It's cleared by an enzyme called DPP4.

>> Dr. Terry Simpson: Long before it ever reaches your brain.

Semaglutide, on the other hand, is synthetic.

It stays active in your body for days.

It's engineered so it can cross the blood brain

barrier, bind to the receptors.

>> Dr. Terry Simpson: And the reward centers, and actually help.

>> Dr. Terry Simpson: You change your behavior.

>> Dr. Terry Simpson: Think about this. If you are trying

to dig a trench and you have

a little tiny shovel like one of those you use.

>> Dr. Terry Simpson: In the garden, it's going to take you forever. You're going to get discouraged and

you're.

>> Dr. Terry Simpson: Going to give up.

>> Dr. Terry Simpson: Get a backhoe. You can do it quickly.

>> Dr. Terry Simpson: GLP1s are like the backhoe.

>> Dr. Terry Simpson: What about sea moss and berberine and all these other

fiber things?

>> Dr. Terry Simpson: They don't do that.

>> Dr. Terry Simpson: If they did, if they could last long in

your body, they'd be prescription drugs.

>> Dr. Terry Simpson: But instead they're Instagram ads.

>> Dr. Terry Simpson: Let's talk about some myths and lies and TikTok

tragedies.

>> Dr. Terry Simpson: Myth one, it's a cheat code.

>> Dr. Terry Simpson: Nope.

>> Dr. Terry Simpson: This does not erase responsibility.

It makes responsible choices

finally possible. Myth

two, you're gonna lose your muscle mass.

>> Dr. Terry Simpson: Well, if your diet is err and.

>> Dr. Terry Simpson: Regret, yeah, it will.

>> Dr. Terry Simpson: But if you eat a reasonable amount of protein, do some lifting,

or do.

>> Dr. Terry Simpson: Some resistance training, you're gonna be fine.

>> Dr. Terry Simpson: M Myth three, you're gonna regain it.

>> Dr. Terry Simpson: All when you stop.

>> Dr. Terry Simpson: You know, if you treat this like a crash diet.

Absolutely. If you use it to help

reset behavior and adjust your lifestyle.

Not necessarily. But uh, remember,

GLP1s are a treatment for

obesity. And just like a treatment for blood pressure

medicine, when your blood pressure gets under control, you don't

stop your blood pressure medicine. When your lipids get under control,

you don't stop your cholesterol medicine. When your

obesity gets under control, you.

>> Dr. Terry Simpson: Don'T stop your GLP1.

>> Dr. Terry Simpson: Myth four, it causes cancer. Well,

if you're a rodent and take.

>> Dr. Terry Simpson: Megadoses of it, you're going to have some thyroid issues,

but not in humans.

>> Dr. Terry Simpson: That's not your worry unless you have a rare genetic

ailment called Men2 syndrome, which

if you're an adult, you know you have it by now and you probably should

not be on a GLP1 unless you're very well

supervised, or if.

>> Dr. Terry Simpson: You'Ve ever had a type of thyroid.

>> Dr. Terry Simpson: Cancer called medullary thyroid cancer.

>> Dr. Terry Simpson: Myth 5 It's totally safe.

>> Dr. Terry Simpson: Nothing is totally safe.

Some suggestions have even suggested a possible link to

a wet macular degeneration and a form of blindness

after long term use, especially in diabetics and

older adults. So if you are diabetic or you are

an older adult, get your eyes checked.

>> Dr. Terry Simpson: If you're on these medications now, that's not

fear, that's follow up.

Now let's talk about some benefits that.

>> Dr. Terry Simpson: Are more than just a smaller pant size.

The select trial showed that there are fewer heart attacks

and fewer strokes. Other studies have shown

that blood sugar is under better control. There's less

liver fat, there is reduced

inflammation. Other studies have shown that it is

an effective treatment for obstructive sleep apnea.

Other studies have shown that it improves kidney function.

Others have suggested a lower dementia risk,

especially when combined with statins.

>> Dr. Terry Simpson: Now, do you want to supercharge your GLP1

experience, go Mediterranean?

>> Dr. Terry Simpson: No, I don't mean go to the.

>> Dr. Terry Simpson: Mediterranean, although I think that's a perfectly good

idea.

>> Dr. Terry Simpson: But studies show that people on GLP1s who

follow a Mediterranean style diet lose

more weight than those who just inject in coastal. The

original studies done on GLP1s done on these patients,

they all were given a Mediterranean style diet to follow,

and.

>> Dr. Terry Simpson: Some were given placebo and some were given GLP1s.

>> Dr. Terry Simpson: Those who followed that do better. When we study

people who are not.

>> Dr. Terry Simpson: Following any sort of a diet, we find

they just don't do as well.

>> Dr. Terry Simpson: As those on the original study. So we're talking more

vegetables, more legumes, more nuts.

We're talking olive oil instead of butter. We're talking

fatty fish instead of processed meat.

So why does the Mediterranean diet work to support this?

>> Dr. Terry Simpson: Well, number one, Mediterranean diet, as you.

>> Dr. Terry Simpson: Know, has a decreased risk of all of those diseases. We're worried

about obesity, diabetes, cardiovascular disease,

strokes, cancers and dementia. And

number two, because Mediterranean diet is rich in

fibrous food, it helps support.

>> Dr. Terry Simpson: Your gut, your gut, hormones, and even.

>> Dr. Terry Simpson: Your body's own natural GLP one response.

Now, the Mediterranean diet has the advantage of it's not just

food in the.

>> Dr. Terry Simpson: Mediterranean, it's food you can get anywhere.

>> Dr. Terry Simpson: The Mediterranean diet is not about restriction. And

this is about synergy.

>> Dr. Terry Simpson: You know, the real problem is stigma.

>> Dr. Terry Simpson: It's not fat. Obesity is

not a character flaw.

>> Dr. Terry Simpson: It is a chronic disease.

>> Dr. Terry Simpson: The American Medical association declared it a chronic

disease in 2013. And the science has

been clear about this for years.

>> Dr. Terry Simpson: It involves genetics, hormones, gut

microbiota, brain.

>> Dr. Terry Simpson: Signaling, and the environment.

>> Dr. Terry Simpson: It's not just about your fork and your discipline.

>> Dr. Terry Simpson: Yet we still get insurance denials.

Predominantly we get insurance denials because

the medicines are too expensive. In the United States,

we have doctors who shame patients instead of

treating patients. We have celebrities who

lie about their use. And, uh, we have

biohacking bros who have no medical license peddling

shortcuts that don't work. Obesity

treatment needs medicine or surgery. Not

moralizing, not magnesium and not

misinformation. GLP1s aren't

a miracle, but they are the start of a metabolic revolution.

They work by quieting the noise in your brain, not

just your belly. And when paired with a Mediterranean

diet, real medical supervision and a little science.

>> Dr. Terry Simpson: Backed support, you've got something powerful.

Please check the blog associated with this

episode@yourdoctorsorders.com and4q.com

this episode was researched and.

>> Dr. Terry Simpson: Written by me, Dr. Terri Simpson. And while I am a board certified.

>> Dr. Terry Simpson: Physician, I am not your physician. If you're on a

GLP1 journey, check.

>> Dr. Terry Simpson: Often with your doctor before making any changes. And with the

registered dietitian associated with your program.

Please don't check with a chiropractor, Eastern.

>> Dr. Terry Simpson: Trained shaman who can't even prescribe these medications.

Check in often with your physician, get monitored,

stay engaged. Support groups

help people lose weight and keep on

track.

>> Dr. Terry Simpson: All things distribution and audio were handled by my friends at

Simpler Media.

>> Dr. Terry Simpson: And the pod got himself my good buddy, Mr.

Evotera. Have a good week everybody.

>> Dr. Terry Simpson: Hey Evo, I think these drugs are.

>> Dr. Terry Simpson: Going to be the source of the next Nobel Prize.

>> Dr. Terry Simpson: They are absolutely amazing and revolutionary in what they can do

for people. Amazing.

>> Dr. Terry Simpson: Have a good week, buddy.

>> Speaker C: Wait, I thought the next peace prize was going to the felon

in chief anyhow. Uh, you my friend,

should win a comedy award for that line if your

diet is air. And regret

I lulled.